Finnish psychiatry professor Erkki Isometsä argues in Helsingin Sanomat (10 March) that antidepressant drug have clear benefits and that I ignore evidence to the contrary. I do not. I have gone carefully through a vast body of research, which includes unpublished data Isometsä has never seen because we got the study reports from the European Medicines Agency. They tell a completely different story to the one that is told in medical journals.